直肠癌和肛管癌的随机临床试验。

Randomized clinical trials in rectal and anal cancers.

作者信息

Park Jason, Neuman Heather B, Weiser Martin R, Wong W Douglas

机构信息

Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

出版信息

Surg Oncol Clin N Am. 2010 Jan;19(1):205-23. doi: 10.1016/j.soc.2009.09.005.

DOI:10.1016/j.soc.2009.09.005

PMID:19914567

Abstract

This article reviews randomized clinical trials (RCTs) published between April 2001 and November 2008 on the management of patients with rectal cancer. In total, the authors reviewed 78 RCTs on therapy for rectal cancer. Of these, five met the authors' criteria for level 1a evidence. The article discusses the major RCTs and relevant findings that have impacted clinical management most and includes most but not all RCTs on therapy for rectal cancer published during this period.

摘要

本文回顾了2001年4月至2008年11月间发表的关于直肠癌患者管理的随机临床试验（RCT）。作者总共回顾了78项关于直肠癌治疗的随机临床试验。其中，有五项符合作者的1a级证据标准。本文讨论了对临床管理影响最大的主要随机临床试验及相关研究结果，涵盖了这一时期发表的关于直肠癌治疗的大部分（但并非全部）随机临床试验。