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甘草次酸衍生物的合成及其在代谢性疾病治疗中的应用。

Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.

机构信息

Inst. Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, Vienna 1060, Austria.

出版信息

Bioorg Med Chem. 2010 Jan 1;18(1):433-54. doi: 10.1016/j.bmc.2009.10.036. Epub 2009 Oct 23.

DOI:10.1016/j.bmc.2009.10.036
PMID:19914836
Abstract

The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11beta-hydroxysteroid dehydrogenase (11beta-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported and discussed.

摘要

研究了甘草次酸（GA）及其衍生物对 11β-羟甾脱氢酶（11β-HSD）的作用。制备了在 GA 骨架的 C-3、C-11 和 C-29 位进行修饰的新型化合物。报道并讨论了所选物质的单晶 X 射线衍射数据。

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