Department of Cardiology Box Hill Hospital, Victoria 3128, Australia.
Heart Lung Circ. 2010 Feb;19(2):63-70. doi: 10.1016/j.hlc.2009.10.002. Epub 2009 Nov 14.
Tako-tsubo cardiomyopathy is an increasingly recognised phenomenon characterised by chest pain, ECG abnormalities, cardiac biomarker elevation and transient left ventricular dysfunction without significant coronary artery obstruction.
To report the clinical and echocardiographic characteristics from a large single-centre Australian series of patients with Tako-tsubo syndrome.
We prospectively collected data on 23 consecutive patients presenting between November 2005 and November 2007. Baseline demographics, ECG, echocardiography and coronary angiography were performed on nearly all patients.
All patients presented with chest pain; 87% were female. Various stressors were noted and cardiac Troponin-T was elevated in 91% of patients. All patients had non-obstructive coronary disease at angiography. 19/23 patients had initial and subsequent echocardiography. Mean ejection fraction was 50% at baseline and 64% at follow-up (p<0.0001). Right ventricular dysfunction was present in eight, dynamic left ventricular outflow tract obstruction in two, diastolic dysfunction in seven and two patients had the mid-cavity variant.
This large prospective single-centre Australian series of Tako-tsubo syndrome is in concert with previous published series. Complete recovery of left ventricular function on echocardiographic follow-up was typical. Although its pathogenesis remains unclear, early distinction from acute coronary syndromes is important and the prognosis is reassuringly good.
心肌气球样变是一种越来越被认可的现象，其特征为胸痛、心电图异常、心脏生物标志物升高和短暂性左心室功能障碍，而无明显冠状动脉阻塞。
报告来自澳大利亚一个大型单中心系列心肌气球样变患者的临床和超声心动图特征。
我们前瞻性地收集了 2005 年 11 月至 2007 年 11 月期间连续 23 例患者的数据。几乎所有患者均进行了基线人口统计学、心电图、超声心动图和冠状动脉造影。
所有患者均出现胸痛；87%为女性。注意到各种应激源，91%的患者心肌肌钙蛋白 T 升高。所有患者在血管造影时均存在非阻塞性冠状动脉疾病。23 例中有 19 例进行了初始和后续超声心动图检查。基线时平均射血分数为 50%，随访时为 64%（p<0.0001）。8 例存在右心室功能障碍，2 例存在动态左心室流出道梗阻，7 例存在舒张功能障碍，2 例存在中段心腔变体。
这项来自澳大利亚的大型前瞻性单中心心肌气球样变系列研究与之前发表的系列研究一致。超声心动图随访时左心室功能的完全恢复是典型的。尽管其发病机制尚不清楚，但早期与急性冠状动脉综合征区分很重要，预后令人安心良好。
