Department of Radiation Oncology, Shandong Tumor Hospital and Institute, Jinan, China.
Ann Oncol. 2010 May;21(5):1078-82. doi: 10.1093/annonc/mdp430. Epub 2009 Nov 13.
The purpose of this study was to evaluate the prognostic value of maximal standard uptake values (SUVs(max)) from serial fluor-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) in patients with locally advanced nasopharyngeal carcinoma (NPC).
From October 2002 to January 2004, 62 patients with locally advanced NPC who underwent (18)F-FDG PET/CT scan before and after radiotherapy were reviewed retrospectively. We examined the association of SUV(max) and the results of long-term follow-up of the patients.
Patients having tumors with a lower SUV(max) had significantly better 5-year overall survival (OS) (P= 0.0187) and disease-free survival (DFS) (P = 0.0163) than patients with a greater SUV(max). The patients who showed with metabolic complete response had a significantly higher 5-year OS (P = 0.0237) and DFS (P = 0.0186) than patients with metabolic partial response. Poor prognosis was found in patients with the SUV(max) of neck nodes larger than that at the primary tumor site (SUV(max-N) > SUV(max-P)) (P = 0.0440).
(18)F-FDG uptake, as measured by the SUV(max) before radiotherapy and metabolic response after radiotherapy, may predict the prognosis in locally advanced NPC. High (18)F-FDG uptake before and after radiotherapy may be useful for identifying patients requiring more aggressive treatment.
本研究旨在评估氟-18-氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）中最大标准摄取值（SUV(max)）在局部晚期鼻咽癌（NPC）患者中的预后价值。
回顾性分析 2002 年 10 月至 2004 年 1 月期间 62 例接受放化疗前 18F-FDG PET/CT 扫描的局部晚期 NPC 患者的资料。我们检查了 SUV(max)与患者长期随访结果之间的关系。
SUV(max)较低的患者 5 年总生存率（OS）（P=0.0187）和无病生存率（DFS）（P=0.0163）显著优于 SUV(max)较高的患者。代谢完全缓解的患者 5 年 OS（P=0.0237）和 DFS（P=0.0186）显著高于代谢部分缓解的患者。SUV(max-N)＞SUV(max-P)（颈淋巴结 SUV(max)大于原发肿瘤部位 SUV(max)）的患者预后较差（P=0.0440）。
放疗前 SUV(max)和放疗后代谢反应可预测局部晚期 NPC 的预后。高放疗前后 18F-FDG 摄取可能有助于识别需要更积极治疗的患者。
