细胞色素P-450侧链裂解酶与细胞色素b5的相互作用。
Interaction of cytochrome P-450scc with cytochrome b5.
作者信息
Usanov S A, Chashchin V L
机构信息
Institute of Bioorganic Chemistry, BSSR Academy of Sciences, Minsk, USSR.
出版信息
FEBS Lett. 1991 Jan 28;278(2):279-82. doi: 10.1016/0014-5793(91)80135-p.
PMID:1991523
Abstract
Spectrophotometric, affinity chromatography and cross-linking experiments provided evidence that cytochrome P-450scc from bovine adrenocortical mitochondria forms a tight complex with cytochrome b5 from rabbit liver microsomes. In the reconstituted system cholesterol side chain activity of cytochrome P-450scc was enhanced by the addition of cytochrome b5.
摘要
分光光度法、亲和层析和交联实验提供了证据，表明牛肾上腺皮质线粒体中的细胞色素P-450scc与兔肝微粒体中的细胞色素b5形成紧密复合物。在重组系统中，添加细胞色素b5可增强细胞色素P-450scc的胆固醇侧链活性。
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