Dr. Jerath's Skin and VD Clinic and Allergy Centre, Jalandhar City, Punjab, India.
Indian J Dermatol Venereol Leprol. 2009 Nov-Dec;75(6):575-8. doi: 10.4103/0378-6323.57717.
The effect of therapeutic circumcision in men for preventing recurrences of herpes genitalis remains largely unelucidated despite its well documented albeit conflicting role in reducing the risk of acquiring sexually transmitted infections, including genital herpes.
Twenty volunteer adult males with a history of recurrent herpes genitalis were included in the study after informed consent and circumcision was carried out. Twenty more adult males having recurrent herpes genitalis and registered in the clinic during the same period were selected as controls. All patients and controls were followed-up for recurrences of herpes genitalis.
Six patients and six controls did not follow-up. Seven patients reported no recurrences during 3-18 years, seven patients had two to six recurrences during 11-27 years of postcircumcision follow-up, 0.0080 (average) recurrences per person per year as compared with 0.20 (average) recurrences per person per year recorded before the circumcision. Two patients had first recurrence 11 years after the circumcision. In comparison, 14 controls had 0.17 (average) recurrences per person per year, comparable with the number of recurrences in uncircumcised patients, and frequently at shorter intervals. Despite being a small study, the circumcision appears to reduce the number of recurrences on an average and evidently prolongs the disease-free period in between two recurrences.
尽管有充分的文献记载表明割礼在降低性传播感染（包括生殖器疱疹）的风险方面具有冲突的作用，但治疗性割礼对预防生殖器疱疹复发的效果仍在很大程度上尚未阐明。
在知情同意并进行割礼后，研究纳入了 20 名有生殖器疱疹复发史的志愿成年男性。在同一时期，在诊所登记有生殖器疱疹复发史的另外 20 名成年男性被选为对照组。所有患者和对照组均进行生殖器疱疹复发的随访。
6 名患者和 6 名对照组未进行随访。7 名患者在 3-18 年内无复发报告，7 名患者在割礼后 11-27 年内有 2-6 次复发，每人每年平均复发 0.0080 次，而割礼前每人每年平均复发 0.20 次。2 名患者在割礼后 11 年首次复发。相比之下，14 名对照组每人每年平均有 0.17 次复发，与未割礼患者的复发次数相当，且复发间隔时间较短。尽管这是一项小型研究，但割礼似乎平均减少了复发次数，并明显延长了两次复发之间的无病期。
