体外受精与胚胎移植、配子输卵管内移植或合子输卵管内移植后多胎妊娠的发生率。

The incidence of multiple pregnancy after in vitro fertilization and embryo transfer, gamete, or zygote intrafallopian transfer.

作者信息

Bollen N, Camus M, Staessen C, Tournaye H, Devroey P, Van Steirteghem A C

机构信息

Center for Reproductive Medicine, Vrije Universiteit Brussel, Belgium.

出版信息

Fertil Steril. 1991 Feb;55(2):314-8. doi: 10.1016/s0015-0282(16)54122-3.

DOI:10.1016/s0015-0282(16)54122-3

PMID:1991529

Abstract

This retrospective study concerns the incidence of multiple pregnancy after the replacement of three conceptus using different techniques of assisted reproduction. During a 2-year period, 713 in vitro fertilization-embryo transfers (IVF-ETs) with three embryos, 190 gamete intrafallopian transfers (GIFT) with three oocytes, and 161 zygote intrafallopian transfers (ZIFT) with three zygotes were performed. Although we observed significant differences in implantation and pregnancy rates (PRs), the three techniques resulted in high multiple PR. At 20 weeks, 16% of GIFT pregnancies, 27% of ZIFT pregnancies, and 32% of IVF-ET pregnancies were multiple. Therefore we recommend to limit the number of conceptus transferred to a maximum of three in all cases.

摘要

这项回顾性研究关注使用不同辅助生殖技术移植三个孕体后多胎妊娠的发生率。在两年时间里，进行了713例移植三个胚胎的体外受精 - 胚胎移植（IVF - ET）、190例移植三个卵母细胞的配子输卵管内移植（GIFT）以及161例移植三个受精卵的合子输卵管内移植（ZIFT）。尽管我们观察到着床率和妊娠率（PRs）存在显著差异，但这三种技术都导致了较高的多胎PR。在孕20周时，GIFT妊娠中有16%为多胎，ZIFT妊娠中有27%为多胎，IVF - ET妊娠中有32%为多胎。因此，我们建议在所有情况下将移植的孕体数量限制在最多三个。