Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP-EPM), São Paulo, Brazil.
Biol Res. 2009;42(3):281-7. Epub 2009 Nov 2.
Sleep disorders have an increased incidence after menopause. The objective of this work was to evaluate the effects of isoflavone on some oxidative stress markers in postmenopausal women complaining of insomnia. Women aged between 50-65 years (n=38) were recruited and assigned to a double-blind placebo controlled study for 4 months. The treated group received 100 mg/day of isoflavones. Blood collections were conducted on three different occasions to assess total glutathione; superoxide dismutase and catalase in erythrocytes; lipid peroxidation; and homocysteine plasma concentrations. No differences between the groups were observed. However, all the patients seem to improve their oxidative stress status and homocysteine concentration after treatment. Superoxide dismutase activity was correlated with age and time of menopause at the beginning of the treatment, but these correlations were no longer observed by the end of the study. Soy isoflavones were not able to overcome the placebo effect for either oxidative stress parameters or homocysteine concentrations.
绝经后睡眠障碍的发病率增加。本研究旨在评估异黄酮对失眠绝经后妇女某些氧化应激标志物的影响。招募年龄在 50-65 岁之间的女性（n=38），并进行为期 4 个月的双盲安慰剂对照研究。治疗组每天服用 100mg 异黄酮。在三个不同的时间点采集血液样本，以评估红细胞中的总谷胱甘肽；超氧化物歧化酶和过氧化氢酶；脂质过氧化；以及血浆同型半胱氨酸浓度。两组之间未观察到差异。然而，所有患者在治疗后似乎都改善了氧化应激状态和同型半胱氨酸浓度。超氧化物歧化酶活性与治疗开始时的年龄和绝经时间相关，但在研究结束时这些相关性不再存在。大豆异黄酮对于氧化应激参数或同型半胱氨酸浓度均不能克服安慰剂效应。
