Wang Shao-Jun, Tan Lian-Hong, Yang Yong-Sheng
Department of Molecular Biology of Acu-moxibustion, Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Zhen Ci Yan Jiu. 2009 Aug;34(4):283-8.
In the present paper, the authors introduce recent progress of application of molecular biological techniques in the studies on the underlying mechanism of acupuncture therapy for 1) resisting inflammation and relieving pain, 2) resisting tumors, 3) improving ischemic cerebral and myocardial injury, and 4) delaying aging from gene transcription and expression (synthesis of mRNA); and for relieving sciatic nerve injury, spinal traumatic injury, and cerebral ischemia from protein expression or phosphorylation. In addition, the authors also make a preliminary analysis on the extant problems of the application of techniques of both genomics and proteomics in acupuncture research at the present and predict their applicable prospect.
在本文中,作者介绍了分子生物学技术在针刺疗法作用机制研究中的最新进展,这些机制包括:1)抗炎止痛;2)抗肿瘤;3)改善缺血性脑损伤和心肌损伤;4)从基因转录和表达(mRNA合成)方面延缓衰老;以及从蛋白质表达或磷酸化方面缓解坐骨神经损伤、脊髓创伤性损伤和脑缺血。此外,作者还对目前基因组学和蛋白质组学技术在针灸研究应用中存在的问题进行了初步分析,并预测了其应用前景。