Giaquinto Carlo, van Damme Pierre
Department of Paediatrics, University of Padua, Via Giustiniani 3, Padua, Italy.
Scand J Infect Dis. 2010;42(2):142-7. doi: 10.3109/00365540903380495.
Rotavirus is the most frequent cause of severe diarrhoea in children aged <5 y. A prospective, multicentre, observational study was conducted in Europe during the 2004-2005 rotavirus season. The study was undertaken in areas of Belgium, France, Germany, Italy, Spain, Sweden, and the UK, to estimate the incidence of community-acquired acute gastroenteritis (AGE) and rotavirus gastroenteritis (RVGE) in children under 5 y of age seeking medical care in 3 settings: primary care, emergency department, and hospital. A post-hoc analysis was done to further describe the age distribution of children with RVGE. The study included 2846 children with AGE. Of 2712 children for whom ELISA results were available, 1102 (40.6%) were rotavirus-positive to the results section well. Overall, 86.1% of RVGE cases occurred in children aged between 3 months and 3 y, whereas 1.8% of cases were observed in infants aged less than 3 months. A total of 3.6% of cases occurred in children aged more than 4 y. These results suggest that, in Europe, routine vaccination for rotavirus should be offered to all infants in early childhood to be effective during the main at-risk period. This could significantly reduce the substantial burden of this potentially serious childhood disease.
轮状病毒是5岁以下儿童严重腹泻最常见的病因。在2004 - 2005年轮状病毒流行季节期间，欧洲开展了一项前瞻性、多中心观察性研究。该研究在比利时、法国、德国、意大利、西班牙、瑞典和英国的部分地区进行，旨在估计在三种就医场景（初级保健机构、急诊科和医院）中寻求医疗服务的5岁以下儿童社区获得性急性胃肠炎（AGE）和轮状病毒胃肠炎（RVGE）的发病率。进行了一项事后分析，以进一步描述RVGE患儿的年龄分布情况。该研究纳入了2846例患有AGE的儿童。在2712例可获得ELISA检测结果的儿童中，1102例（40.6%）轮状病毒检测呈阳性，结果良好。总体而言，86.1%的RVGE病例发生在3个月至3岁的儿童中，而1.8%的病例在3个月以下的婴儿中观察到。共有3.6%的病例发生在4岁以上的儿童中。这些结果表明，在欧洲，应在幼儿期为所有婴儿提供轮状病毒常规疫苗接种，以便在主要风险期发挥作用。这可显著减轻这种潜在严重儿童疾病的沉重负担。
