Chaib E, Fridman C, Massad E
Department of Gastroenterology, Hospital das Clinicas, University of São Paulo School of Medicine, São Paulo, Brazil.
Transplant Proc. 2009 Nov;41(9):3775-8. doi: 10.1016/j.transproceed.2009.05.035.
Liver transplantation increased 1.84-fold from 1988 to 2004. However, the number of patients on the waiting list for a liver increased 2.71-fold, from 553 to 1500. We used a mathematical equation to analyze the potential effect of using ABO-compatible living-donor liver transplantation (LDLT) on both our liver transplantation program and the waiting list. We calculated the prevalence distribution of blood groups (O, A, B, and AB) in the population and the probability of having a compatible parent or sibling for LDLT. The incidence of ABO compatibility in the overall population was as follows: A, 0.31; B, 0.133; O, 0.512; and AB, 0.04. The ABO compatibility for parent donors was blood group A, 0.174; B, 0.06; O, 0.152; and AB, 0.03; and for sibling donors was A, 0.121; B, 0.05; O, 0.354; and AB, 0.03. Use of LDLT can reduce the pressure on our liver transplantation waiting list by decreasing its size by at least 16.5% at 20 years after its introduction. Such a program could save an estimated 3600 lives over the same period.
从1988年到2004年，肝移植数量增长了1.84倍。然而，等待肝移植的患者人数增长了2.71倍，从553人增至1500人。我们使用一个数学方程来分析采用ABO血型相容的活体供肝肝移植（LDLT）对我们的肝移植项目和等待名单可能产生的影响。我们计算了人群中血型（O、A、B和AB）的流行分布以及有LDLT相容的父母或兄弟姐妹的概率。总体人群中ABO血型相容的发生率如下：A，0.31；B，0.133；O，0.512；AB，0.04。父母供体的ABO血型相容性为：血型A，0.174；B，0.06；O，0.152；AB，0.03；兄弟姐妹供体的为：A，0.121；B，0.05；O，0.354；AB，0.03。采用LDLT可以减轻我们肝移植等待名单的压力，在引入后20年时使名单规模至少缩小16.5%。这样一个项目在同一时期估计可挽救3600条生命。
