Mannelli F, De Simone P, Gianfaldoni G, Nozzoli C, Filipponi F, Bosi A
Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy.
Transplant Proc. 2009 Nov;41(9):3945-6. doi: 10.1016/j.transproceed.2009.06.194.
Acute myeloid leukemia (AML) has been rarely reported after transplantation, namely seven cases described so far. The putative mechanism of action is long-standing immunosuppression, even though no clear correlation with the type of drug has ever been demonstrated. We report the case of a 28-year-old male patient who presented with a early onset of AML after liver transplantation for hepatitis B virus-related acute liver failure. The AML was characterized by aggressive clinical features with extrahematologic sites of involvement and an atypical immunophenotype; the laboratory findings were consistent with the diagnosis of monocytic acute leukemia.
移植后发生急性髓系白血病（AML）的情况鲜有报道，迄今为止仅描述了7例。其假定的作用机制是长期免疫抑制，尽管尚未证实与药物类型有明确关联。我们报告了一例28岁男性患者，该患者因乙型肝炎病毒相关急性肝衰竭接受肝移植后早期发生AML。该AML具有侵袭性临床特征，伴有血液外受累部位和非典型免疫表型；实验室检查结果符合单核细胞急性白血病的诊断。
