新型含 1,2,3-三唑残基的 2',3'-二脱氧-2',3'-二乙硫代核苷的合成及抗肿瘤活性。
Synthesis and antitumor activity of novel 2',3'-dideoxy-2',3'-diethanethionucleosides bearing 1,2,3-triazole residues.
机构信息
School of Chemical Engineering & Environment, Beijing Institute of Technology, Beijing 100081, China.
出版信息
Bioorg Med Chem Lett. 2010 Jan 1;20(1):240-3. doi: 10.1016/j.bmcl.2009.10.127. Epub 2009 Nov 4.
PMID:19917528
Abstract
A series of novel 2',3'-dideoxy-2',3'-diethanethioribonucleosides and those modified with a triazole ring were prepared in excellent yields and their antitumor activity was evaluated. Nucleosides with a triazole ring, 16a-16c, showed significantly improved activity towards a broad range of tumor cell lines.
摘要
一系列新型 2',3'-二脱氧-2',3'-二乙硫代核苷和带有三唑环的修饰核苷被以优异的产率制备，并评估了它们的抗肿瘤活性。带有三唑环的核苷 16a-16c 对广泛的肿瘤细胞系显示出显著改善的活性。
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