Department of Radiation Oncology, University Hospital Ramón y Cajal, Madrid, Spain.
Clin Transl Oncol. 2009 Nov;11(11):760-4. doi: 10.1007/s12094-009-0439-2.
Non-melanoma skin tumours (NMSC) are one of the most frequent types of cancer, accounting for nearly one third of newly diagnosed tumours. NMSC are frequently diagnosed in elderly patients and while mortality rates are low, NMSC can be associated with significant morbidity in terms of cosmetic and functional impairment.
Surgical excision is nowadays considered the standard treatment for NMSC, although this approach might not be suitable for all the patients. Good rates of local control and cosmetic outcome are achieved by using high-dose-rate (HDR) plesiotherapy.
Nine consecutive patients with 11 NMSC were treated with custom-made moulds and HDR plesiotherapy reaching a fi nal dose of 44-48 Gy in 11-12 fractions of 4 Gy over 4 weeks.
No local or distant relapses have been observed after a mean follow-up of 15 months (range 4-36 months). Acute toxicity was acceptable and cosmetic result was considered as excellent/good in 7 patients.
This modality of treatment offers an alternative for those patients not candidates for surgical procedures because of medical contraindications or risk of disfigurement or functional impairment.
非黑色素瘤皮肤肿瘤（NMSC）是最常见的癌症类型之一，占新诊断肿瘤的近三分之一。NMSC 常发生于老年患者，虽然死亡率较低，但 NMSC 可能会导致严重的美容和功能损害。
手术切除目前被认为是 NMSC 的标准治疗方法，但并非所有患者都适用。高剂量率（HDR）近距离放疗可实现良好的局部控制和美容效果。
对 9 例 11 处 NMSC 患者采用定制模具和 HDR 近距离放疗，在 4 周内共 11-12 次，每次 4 Gy，最终剂量为 44-48 Gy。
平均随访 15 个月（4-36 个月）后，未观察到局部或远处复发。急性毒性可接受，7 例患者的美容效果被认为极好/好。
对于因医学禁忌或毁容或功能损害风险而不适合手术的患者，这种治疗方式提供了一种替代选择。
