Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Spinal Cord. 2010 Jun;48(6):483-6. doi: 10.1038/sc.2009.156. Epub 2009 Nov 17.
Pilot study.
To study the effect of pulsatile bolus infusion of intrathecal baclofen (ITB) on daily ITB dose, in patients showing dose increases, probably due to tolerance.
Department of neurology and neurosurgery, University Medical Center Groningen, the Netherlands.
Data on dosages and clinical efficacy were gathered from four patients who were switched from continuous to pulsatile bolus infusion of ITB, because of the probable diagnosis of tolerance to ITB.
Switching from continuous to pulsatile bolus infusion resulted in a decrease of the daily ITB dose, while the clinical effect could be kept stable, without introducing adverse events.
Pulsatile bolus infusion of ITB seems to be an effective and safe treatment strategy to reverse the need for increasing ITB dosages in patients with the probable diagnosis of tolerance to ITB.
初步研究。
研究鞘内注射巴氯芬（ITB）脉冲式推注对每日 ITB 剂量的影响，这些患者可能由于耐受而需要增加剂量。
荷兰格罗宁根大学医学中心神经内科和神经外科。
对因可能诊断为 ITB 耐受而从连续输注切换到 ITB 脉冲式推注的 4 名患者的剂量和临床疗效数据进行了收集。
从连续输注切换到脉冲式推注导致每日 ITB 剂量降低，而临床效果保持稳定，没有引入不良反应。
ITB 脉冲式推注似乎是一种有效且安全的治疗策略，可逆转可能因耐受而需要增加 ITB 剂量的患者的治疗需求。
