Chiang Elizabeth, Packer Clifford D
Department of Neuroscience, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
Cases J. 2009 Aug 13;2:6988. doi: 10.4076/1757-1626-2-6988.
Warm antibody autoimmune hemolytic anemia is due to the presence of warm agglutinins that react with protein antigens on the surface of red blood cells causing premature destruction of circulating red blood cells. We report the first case of concurrent reactive arthritis, Graves' disease, and autoimmune hemolytic anemia. A 40-year-old man with reactive arthritis, Graves' disease, type 2 diabetes mellitus, mitral valve prolapse, and Gilbert's disease presented with a one month history of jaundice, fatigue, and black stools. After diagnosis of warm autoimmune hemolytic anemia, the patient was started on prednisone 1 mg/kg with rapid improvement in his anemia and jaundice. Our subject's mother and possibly his maternal grandmother also had autoimmune hemolytic anemia, which raises the possibility of hereditary autoimmune hemolytic anemia, a rarely reported condition.
温抗体型自身免疫性溶血性贫血是由于存在温凝集素，其与红细胞表面的蛋白质抗原发生反应，导致循环中的红细胞过早破坏。我们报告了首例并发反应性关节炎、格雷夫斯病和自身免疫性溶血性贫血的病例。一名患有反应性关节炎、格雷夫斯病、2型糖尿病、二尖瓣脱垂和吉尔伯特综合征的40岁男性，出现黄疸、疲劳和黑便1个月病史。在诊断为温抗体型自身免疫性溶血性贫血后，患者开始服用泼尼松1mg/kg，贫血和黄疸迅速改善。我们患者的母亲以及可能他的外祖母也患有自身免疫性溶血性贫血，这增加了遗传性自身免疫性溶血性贫血的可能性，这是一种很少报道的疾病。
