一种简洁的方法构建利迪链菌素 B，一种抗分枝杆菌的环二肽。
A concise route to the proposed structure of lydiamycin B, an antimycobacterial depsipeptide.
机构信息
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
出版信息
Org Lett. 2009 Dec 17;11(24):5694-7. doi: 10.1021/ol9024474.
PMID:19919082
Abstract
The total synthesis of four possible isomers with the proposed structure of antimycobacterial depsipeptide lydiamycin B is achieved. None of them shows identical NMR data with those reported for natural lydiamycin B, indicating that further structural revisions are required.
摘要
四种可能的立体异构体与具有抗分枝杆菌环二肽利迪链菌素 B 结构的提议结构的全合成已完成。它们都没有显示出与天然利迪链菌素 B 报道的数据相同的 NMR 数据，表明需要进一步的结构修订。
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