透皮传递尼群地平的整体基质聚合物薄膜的配方与评价。

Formulation and evaluation of monolithic matrix polymer films for transdermal delivery of nitrendipine.

机构信息

ITS-Paramedical (Pharmacy) College, Ghaziabad, India.

出版信息

Acta Pharm. 2009 Dec;59(4):383-93. doi: 10.2478/v10007-009-0032-9.

PMID:19919928

Abstract

The objective of the present work was to develop a suitable transdermal drug delivery system for nitrendipine. Polymeric films of nitrendipine were prepared by the film casting technique (glass ring) on mercury substrate. They were evaluated for physicochemical parameters, in vitro release and ex vivo permeation (heat separated human epidermis). Release of the drug from the films followed anomalous transport (0.5 < n < 1).Polymeric combination containing Eudragit RL 100:PVP K 30 in a 4:6 ratio showed the best results. Maximum drug release and skin permeability coefficient in 48 h were 85.8% and 0.0142 cm h(-1), respectively, in formulation C3 (Eudragit RL 100/Plasdone S 630; 4:6) and 88.0% and 0.0155 cm h(-1), respectively, in formulation, D3 (Eudragit RL 100/PVP K 30; 4:6). FTIR and TLC studies indicated no drug and polymer interaction.

摘要

本工作旨在开发一种适合硝苯地平的经皮给药系统。采用玻璃环在汞基底上的涂膜技术制备硝苯地平的聚合物薄膜。对其进行了物理化学参数、体外释放和离体渗透（热分离人体表皮）的评价。药物从薄膜中的释放遵循异常传递（0.5 < n < 1）。以 Eudragit RL 100：PVP K 30 为 4：6 比例的聚合物组合显示出最佳效果。在配方 C3（Eudragit RL 100/Plasdone S 630；4：6）中，48 小时内药物释放和皮肤渗透系数最大分别为 85.8%和 0.0142 cm h(-1)，在配方 D3（Eudragit RL 100/PVP K 30；4：6）中最大分别为 88.0%和 0.0155 cm h(-1)。FTIR 和 TLC 研究表明药物和聚合物之间没有相互作用。