Doheny Eye Institute, Departments of Physiology and Biophysics and *Ophthalmology, University of Southern California, Los Angeles, California, U.S.A.
J Glaucoma. 1994 Summer;3(2):140-51.
Single-plate Molteno implants were installed in two stages in glaucomatous monkey eyes. This device shunts aqueous from the anterior chamber to periocular orbital tissues. The mechanism of aqueous filtration and absorption was explored using flow studies, fluorescently labeled microspheres and histological examination of tissues. Flow studies indicated that the capsule around the explant functions by a passive mechanism, shunting aqueous into the extracellular space. Outflow is proportional to capsule surface area. Latex microspheres (0.2 mum and smaller) passed freely through the capsule, giving the impression of an open sieve. The presence of microspheres in the episcleral wall of the capsule indicates that all surfaces contribute to filtration. A concentration gradient of particles in the extracapsular space, away from the bleb surface, suggests that the capsule itself limits filtration rate.
单页式Molteno 植入物分两期植入青光眼猴眼。该装置将房水从前房引流到眼周眶组织。使用流量研究、荧光标记微球和组织学检查来探索房水过滤和吸收的机制。流量研究表明，植入物周围的囊通过被动机制起作用，将房水引流到细胞外空间。流出量与囊表面积成正比。乳胶微球（0.2 微米及更小）自由通过囊，给人一种筛子打开的印象。微球存在于囊的巩膜壁表明所有表面都有助于过滤。在远离囊泡表面的囊外空间中存在颗粒的浓度梯度表明，囊本身限制了过滤速度。
