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Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain.

作者信息

Marchalant Y, Brothers H M, Wenk G L

出版信息

Mol Psychiatry. 2009 Dec;14(12):1068-9. doi: 10.1038/mp.2009.62.

DOI:10.1038/mp.2009.62
PMID:19920834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3011092/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfdc/3011092/37e8d291aac5/mp200962f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfdc/3011092/37e8d291aac5/mp200962f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfdc/3011092/37e8d291aac5/mp200962f1.jpg

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本文引用的文献

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Neurobiol Dis. 2009 May;34(2):300-7. doi: 10.1016/j.nbd.2009.01.014.
2
Hippocampal neurogenesis during normal and pathological aging.正常衰老和病理性衰老过程中的海马神经发生
Psychoneuroendocrinology. 2007 Aug;32 Suppl 1:S26-30. doi: 10.1016/j.psyneuen.2007.04.014. Epub 2007 Jul 12.
3
Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats.大麻素受体刺激具有抗炎作用，并能改善老年大鼠的记忆力。
低剂量 ∆9-四氢大麻酚可减轻阿尔茨海默病相关认知障碍，并调节 5XFAD 小鼠模型中脑源性神经营养因子受体表达。
Int J Mol Sci. 2022 Aug 21;23(16):9449. doi: 10.3390/ijms23169449.
4
WIN55,212-2 Attenuates Cognitive Impairments in AlCl + d-Galactose-Induced Alzheimer's Disease Rats by Enhancing Neurogenesis and Reversing Oxidative Stress.WIN55,212-2通过增强神经发生和逆转氧化应激减轻氯化铝和d-半乳糖诱导的阿尔茨海默病大鼠的认知障碍。
Biomedicines. 2021 Sep 19;9(9):1270. doi: 10.3390/biomedicines9091270.
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Efficacy of Phytocannabinoids in Epilepsy Treatment: Novel Approaches and Recent Advances.植物大麻素治疗癫痫的疗效：新方法和最新进展。
Int J Environ Res Public Health. 2021 Apr 10;18(8):3993. doi: 10.3390/ijerph18083993.
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The Cannabinoid Receptor Agonist WIN55,212-2 Ameliorates Hippocampal Neuronal Damage After Chronic Cerebral Hypoperfusion Possibly Through Inhibiting Oxidative Stress and ASK1-p38 Signaling.大麻素受体激动剂 WIN55,212-2 通过抑制氧化应激和 ASK1-p38 信号通路改善慢性脑低灌注后的海马神经元损伤。
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Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation.大麻素激动剂WIN-55212-2在慢性脑部炎症啮齿动物模型中的抗炎特性。
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