Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Córdoba, Argentina.
Int J Neurosci. 2009;119(8):1210-27. doi: 10.1080/00207450802324713.
The aim of this work was to determine the effect of chronic treatment with 5 mg/kg of tianeptine in male adult Wistar rats separated from the mother as neonates and submitted to variable chronic stress, plasma catecholamines, and anxiety. The plus maze test was performed in order to calculate the anxiety index and catecholamine levels were determined by high-pressure liquid chromatography. Both stress and maternal separation elevated catecholamine levels without affecting anxiety. In the maternally separated stress group, tianeptine decreased epinephrine. Anxiety was reduced in the maternally separated unstressed tianeptine group. Also, all groups showed a tendency to lower anxiety index.
本研究旨在探讨慢性给予 5mg/kg 噻奈普汀对新生期与母鼠分离并接受变应性慢性应激的雄性成年 Wistar 大鼠的影响，检测血浆儿茶酚胺和焦虑水平。采用高架十字迷宫实验计算焦虑指数，高效液相色谱法测定儿茶酚胺水平。应激和母婴分离均升高儿茶酚胺水平，但不影响焦虑水平。母婴分离应激组中，噻奈普汀降低肾上腺素。未应激母婴分离的噻奈普汀组焦虑减轻。所有组均表现出降低焦虑指数的趋势。
