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Expression of JNK-interacting protein JIP-1 and insulin-like growth factor II in Wilms tumour cell lines and primary Wilms tumours.JNK相互作用蛋白JIP-1和胰岛素样生长因子II在肾母细胞瘤细胞系及原发性肾母细胞瘤中的表达
Anticancer Res. 2009 Jul;29(7):2467-72.
2
Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins.支架蛋白对信号持续时间的调控及激酶激活的统计动力学
PLoS Comput Biol. 2008 Jun 27;4(6):e1000099. doi: 10.1371/journal.pcbi.1000099.
3
Ablation of the scaffold protein JLP causes reduced fertility in male mice.支架蛋白JLP的缺失导致雄性小鼠生育力下降。
Transgenic Res. 2008 Dec;17(6):1045-58. doi: 10.1007/s11248-008-9191-6. Epub 2008 Jun 24.
4
Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein.VRK2与JIP1支架蛋白相互作用对白细胞介素-1转录反应的调节
PLoS One. 2008 Feb 20;3(2):e1660. doi: 10.1371/journal.pone.0001660.
5
Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death.小鼠中支架蛋白JSAP1的神经特异性消融导致新生死亡。
Neurosci Lett. 2007 Dec 11;429(1):43-8. doi: 10.1016/j.neulet.2007.09.057. Epub 2007 Oct 2.
6
Scaffold proteins confer diverse regulatory properties to protein kinase cascades.支架蛋白赋予蛋白激酶级联反应多种调控特性。
Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13307-12. doi: 10.1073/pnas.0706311104. Epub 2007 Aug 8.
7
Regulation of the Pro-apoptotic scaffolding protein POSH by Akt.Akt对促凋亡支架蛋白POSH的调控。
J Biol Chem. 2007 Jul 27;282(30):21987-97. doi: 10.1074/jbc.M704321200. Epub 2007 May 29.
8
Scaffold proteins of MAP-kinase modules.丝裂原活化蛋白激酶模块的支架蛋白。
Oncogene. 2007 May 14;26(22):3185-202. doi: 10.1038/sj.onc.1210411.
9
Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase.巨噬细胞糖皮质激素受体通过选择性抑制p38丝裂原活化蛋白激酶来调节Toll样受体4介导的炎症反应。
Blood. 2007 May 15;109(10):4313-9. doi: 10.1182/blood-2006-10-048215. Epub 2007 Jan 25.
10
Atypical mitogen-activated protein kinases: structure, regulation and functions.非典型丝裂原活化蛋白激酶：结构、调节与功能
Biochim Biophys Acta. 2007 Aug;1773(8):1376-87. doi: 10.1016/j.bbamcr.2006.11.001. Epub 2006 Nov 7.

支架蛋白在 JNK 信号通路中的作用。

The role of scaffold proteins in JNK signalling.

机构信息

Department of Zoology, University of Oxford, Oxford, UK.

出版信息

Cell Prolif. 2010 Feb;43(1):56-66. doi: 10.1111/j.1365-2184.2009.00654.x. Epub 2009 Nov 17.

DOI:10.1111/j.1365-2184.2009.00654.x
PMID:19922489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6496263/
Abstract

This paper summarises how scaffold proteins affects and regulate the JNK signalling pathway. We believe that some of these scaffold proteins, by virtue of their anchoring and catalytic properties contribute to a high degree of specificity of intra cellular signalling pathways that regulate the progression through the cell cycle.

摘要

本文总结了支架蛋白如何影响和调节 JNK 信号通路。我们认为，其中一些支架蛋白凭借其锚定和催化特性，为调节细胞周期进程的细胞内信号通路的高度特异性做出了贡献。