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The role of scaffold proteins in JNK signalling.
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Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways.
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Reassembly of JIP1 scaffold complex in JNK MAP kinase pathway using heterologous protein interactions.
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WDR62 mediates TNFα-dependent JNK activation via TRAF2-MLK3 axis.
Mol Biol Cell. 2018 Oct 1;29(20):2470-2480. doi: 10.1091/mbc.E17-08-0504. Epub 2018 Aug 9.
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Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain.
J Neurochem. 2006 Jun;97(5):1431-46. doi: 10.1111/j.1471-4159.2006.03835.x. Epub 2006 Apr 5.

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A toxic gain-of-function variant in MAPK8IP3 provides insights into JIP3 cellular roles.
JCI Insight. 2025 Mar 20;10(8). doi: 10.1172/jci.insight.187199. eCollection 2025 Apr 22.
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The SIRT5-JIP4 interaction promotes osteoclastogenesis by modulating RANKL-induced signaling transduction.
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MAPK8IP2 is a potential prognostic biomarker and promote tumor progression in prostate cancer.
BMC Cancer. 2022 Nov 11;22(1):1162. doi: 10.1186/s12885-022-10259-2.
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Short Arrestin-3-Derived Peptides Activate JNK3 in Cells.
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Clinically Precedented Protein Kinases: Rationale for Their Use in Neurodegenerative Disease.
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E6-induced selective translation of WNT4 and JIP2 promotes the progression of cervical cancer via a noncanonical WNT signaling pathway.
Signal Transduct Target Ther. 2019 Sep 13;4:32. doi: 10.1038/s41392-019-0060-y. eCollection 2019.
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SPAG9 promotes prostate cancer proliferation and metastasis via MAPK signaling pathway.
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2
Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins.
PLoS Comput Biol. 2008 Jun 27;4(6):e1000099. doi: 10.1371/journal.pcbi.1000099.
3
Ablation of the scaffold protein JLP causes reduced fertility in male mice.
Transgenic Res. 2008 Dec;17(6):1045-58. doi: 10.1007/s11248-008-9191-6. Epub 2008 Jun 24.
5
Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death.
Neurosci Lett. 2007 Dec 11;429(1):43-8. doi: 10.1016/j.neulet.2007.09.057. Epub 2007 Oct 2.
6
Scaffold proteins confer diverse regulatory properties to protein kinase cascades.
Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13307-12. doi: 10.1073/pnas.0706311104. Epub 2007 Aug 8.
7
Regulation of the Pro-apoptotic scaffolding protein POSH by Akt.
J Biol Chem. 2007 Jul 27;282(30):21987-97. doi: 10.1074/jbc.M704321200. Epub 2007 May 29.
8
Scaffold proteins of MAP-kinase modules.
Oncogene. 2007 May 14;26(22):3185-202. doi: 10.1038/sj.onc.1210411.
10
Atypical mitogen-activated protein kinases: structure, regulation and functions.
Biochim Biophys Acta. 2007 Aug;1773(8):1376-87. doi: 10.1016/j.bbamcr.2006.11.001. Epub 2006 Nov 7.

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