Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh, UK.
Histopathology. 2009 Dec;55(6):683-6. doi: 10.1111/j.1365-2559.2009.03438.x.
CD98 is a component of the large neutral amino acid transporter (LAT), which is a cell surface amino acid transporter. CD98 also binds to and activates beta(1)-integrin, promoting anchorage-independent growth. CD98 expression is increased in a variety of carcinomas but its distribution in the normal and neoplastic thyroid gland has not been reported. The aim was to examine the immunohistochemical expression of CD98 in normal and diseased thyroid tissue.
One hundred and forty thyroid cases were selected from the archives of the Department of Pathology, including normal controls, neoplasms (follicular adenoma, follicular carcinoma and papillary carcinoma) and non-neoplastic conditions (multinodular goitre, Graves' disease and Hashimoto's thyroiditis). Immunohistochemistry for CD98 was performed and each case was scored for proportion of cells and intensity of immunoreactivity. In normal thyroid, there was moderately strong expression of CD98 in the lateral cell membranes of follicular cells. A similar pattern of expression was seen in follicular adenoma, minimally invasive follicular carcinoma, multinodular goitre and Graves' disease. In most cases of papillary carcinoma and in the inflamed areas of Hashimoto's thyroiditis, expression of CD98 was decreased.
CD98 expression is down-regulated in thyroid papillary carcinoma; this may relate to the better prognosis associated with many of these tumours.
CD98 是大中性氨基酸转运体（LAT）的组成部分，LAT 是一种细胞表面氨基酸转运体。CD98 还与β（1）整合素结合并激活，促进无锚定生长。CD98 的表达在多种癌中增加，但在正常和肿瘤甲状腺中的分布尚未报道。目的是检查 CD98 在正常和病变甲状腺组织中的免疫组织化学表达。
从病理学系的档案中选择了 140 例甲状腺病例，包括正常对照、肿瘤（滤泡性腺瘤、滤泡癌和乳头状癌）和非肿瘤疾病（多结节性甲状腺肿、Graves 病和桥本甲状腺炎）。进行了 CD98 的免疫组织化学检测，并对每个病例的细胞比例和免疫反应强度进行评分。在正常甲状腺中，滤泡细胞的侧细胞膜中 CD98 表达中度强烈。在滤泡性腺瘤、微侵袭性滤泡癌、多结节性甲状腺肿和 Graves 病中也观察到类似的表达模式。在大多数乳头状癌病例和桥本甲状腺炎的炎症区域，CD98 的表达降低。
甲状腺乳头状癌中 CD98 的表达下调；这可能与许多此类肿瘤相关的更好预后有关。
