Gimsing S
Department of Audiology, Vejle Hospital, Denmark.
J Laryngol Otol. 2010 Mar;124(3):258-64. doi: 10.1017/S0022215109991423. Epub 2009 Nov 19.
(1) To compare audiometric parameters in patients with vestibular schwannoma and in those with asymmetric hearing loss from other causes; and (2) to assess proposed screening criteria by comparing published protocols.
Audiometric data from 199 vestibular schwannoma patients and 225 non-tumour patients were compared. Eight screening protocols were tested on these 424 patients.
Vestibular schwannoma and non-tumour patients with little or no hearing loss in the unaffected ear were inseparable; however, vestibular schwannoma patients with hearing loss in the unaffected ear had greater audiometric asymmetry, compared with non-tumour patients with the same pattern of hearing loss. The sensitivity of screening protocols varied from 73 to 100 per cent; parallelism was observed between sensitivity and screening rate.
As regards vestibular schwannoma screening protocols, the best compromise between sensitivity and screening rate was offered by a criterion comprising either: (1) > or =20 dB asymmetry at two neighbouring frequencies, or unilateral tinnitus, or (2) > or =15 dB asymmetry at two frequencies between 2 and 8 kHz.
（1）比较前庭神经鞘瘤患者与其他原因导致的不对称听力损失患者的听力测定参数；（2）通过比较已发表的方案来评估提议的筛查标准。
比较了199例前庭神经鞘瘤患者和225例非肿瘤患者的听力测定数据。对这424例患者测试了8种筛查方案。
患侧耳几乎无听力损失或无听力损失的前庭神经鞘瘤患者和非肿瘤患者难以区分；然而，与具有相同听力损失模式的非肿瘤患者相比，患侧耳有听力损失的前庭神经鞘瘤患者听力测定不对称性更大。筛查方案的敏感性从73%到100%不等；敏感性与筛查率之间存在平行关系。
关于前庭神经鞘瘤筛查方案，以下标准在敏感性和筛查率之间提供了最佳折衷：（1）两个相邻频率处不对称性≥20dB，或单侧耳鸣，或（2）2至8kHz之间两个频率处不对称性≥15dB。
