在WASH中分拣内体。
Sorting out endosomes in the WASH.
作者信息
Bear James E
机构信息
HHMI, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
出版信息
Dev Cell. 2009 Nov;17(5):583-4. doi: 10.1016/j.devcel.2009.10.019.
PMID:19922862
Abstract
Two new studies published in this issue of Developmental Cell by Derivery et al. and Gomez and Billadeau reveal that WASH (Wiskott-Aldrich syndrome protein and SCAR homolog) activates Arp2/3 on endosomes and plays a critical role in the fission of tubules that serve as transport intermediates during endosome sorting.
摘要
本期《发育细胞》杂志上发表的两项新研究，即德利维等人以及戈麦斯和比拉多所做的研究，揭示了WASH（威斯科特-奥尔德里奇综合征蛋白和SCAR同源物）在内体上激活Arp2/3，并在作为内体分选过程中运输中间体的小管裂变中起关键作用。
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