Wu Gang, Wang Zan-Zhi, Wang Yang, Fu Juan, Xu Li-Jun
Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2009 Nov;29(11):2262-5.
To explore the correlation of serum estradiol, testosterone and their ratio to the injury severity score (ISS) and Glasgow coma score (GCS) in patients with multiple traumatic injuries.
The serum levels of estradiol and testosterone were determined by radioimmunoassay double antibody precipitation method in 95 patients with multiple traumatic injuries within 24 h after trauma. The patients were grouped according to the ISS or GCS (in cases with craniocerebral injury) for comparison of the serum estradiol and testosterone levels with those in 15 normal individuals.
In the acute stage of multiple trauma, a distinct declination of testosterone and a marked increment of estradiol were observed, and the changes were closely related to the severity of the trauma .The serum levels of estradiol and testosterone and their ratio differed significantly between patients with severe trauma (ISS>25) and the other groups (P<0.01), and also between patients with craniocerebral injury (with GCS of 3-5 or 5-8) and the other groups (P<0.01).
Serum estradiol and testosterone levels and their ratio are correlated to the severity of trauma and craniocerebral injuries, and may serve as indicators for evaluating the trauma severity and prognosis of the traumatic patients.
探讨多发伤患者血清雌二醇、睾酮水平及其比值与损伤严重度评分（ISS）和格拉斯哥昏迷评分（GCS）的相关性。
采用放射免疫双抗体沉淀法测定95例多发伤患者伤后24 h内血清雌二醇和睾酮水平。根据ISS或GCS（颅脑损伤患者）对患者进行分组，将血清雌二醇和睾酮水平与15名正常个体进行比较。
多发伤急性期，睾酮水平明显下降，雌二醇水平显著升高，且这些变化与创伤严重程度密切相关。重度创伤患者（ISS>25）与其他组之间血清雌二醇和睾酮水平及其比值差异有统计学意义（P<0.0l），颅脑损伤患者（GCS为3 - 5或5 - 8）与其他组之间差异也有统计学意义（P<0.0l）。
血清雌二醇、睾酮水平及其比值与创伤及颅脑损伤严重程度相关，可作为评估创伤患者创伤严重程度及预后的指标。
