Matthews Lucy A E, Baig Fahd, Palace Jacqueline, Turner Martin R
Specialist Registrar in Neurology, Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK.
Pract Neurol. 2009 Dec;9(6):335-40. doi: 10.1136/jnnp.2009.193888.
Neuromyelitis optica (NMO), also known as Devic's disease, is an emerging clinical and pathological entity originally thought to be a variant of multiple sclerosis. Characterised by episodes of demyelination confined to the optic nerve and spinal cord, the discovery in such patients of antibodies to the aquaporin-4 channel has been largely responsible for defining the phenotype to date. Recently it has become clear that there is a borderland where there are patients with optic neuritis-only and myelitis-only forms of the disease, and these may be seronegative in the early phase. We describe two cases of optic neuritis-only NMO, and explore the current understanding of the diagnosis and spectrum of NMO disorders.
视神经脊髓炎（NMO），也被称为德维克病，是一种新出现的临床和病理实体，最初被认为是多发性硬化症的一种变体。其特征为局限于视神经和脊髓的脱髓鞘发作，迄今为止，在这类患者中发现水通道蛋白4通道抗体在很大程度上有助于明确该疾病的表型。最近已经明确，存在一个临界区域，有仅表现为视神经炎和仅表现为脊髓炎形式的患者，并且这些患者在疾病早期可能血清学呈阴性。我们描述了两例仅表现为视神经炎的NMO病例，并探讨了目前对视神经脊髓炎谱系障碍诊断的认识。
