• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

The hedgehog pathway and pancreatic cancer.

作者信息

Hidalgo Manuel, Maitra Anirban

机构信息

Clinical Research Program, Centro Nacional de Investigaciones Oncológicas, Madrid.

出版信息

N Engl J Med. 2009 Nov 19;361(21):2094-6. doi: 10.1056/NEJMcibr0905857.

DOI:10.1056/NEJMcibr0905857
PMID:19923581
Abstract
摘要

相似文献

1
The hedgehog pathway and pancreatic cancer.刺猬信号通路与胰腺癌
N Engl J Med. 2009 Nov 19;361(21):2094-6. doi: 10.1056/NEJMcibr0905857.
2
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.在胰腺癌小鼠模型中,抑制刺猬信号通路可增强化疗药物的递送。
Science. 2009 Jun 12;324(5933):1457-61. doi: 10.1126/science.1171362. Epub 2009 May 21.
3
Hedgehog pathway inhibition and the race against tumor evolution. hedgehog 通路抑制与肿瘤进化赛跑。
J Cell Biol. 2012 Oct 15;199(2):193-7. doi: 10.1083/jcb.201207140.
4
Hedgehog- and mTOR-targeted therapies for advanced basal cell carcinomas.针对晚期基底细胞癌的刺猬信号通路和雷帕霉素靶蛋白靶向疗法。
Future Oncol. 2015 Nov;11(22):2997-3002. doi: 10.2217/fon.15.181. Epub 2015 Oct 5.
5
Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway.邻联苯甲酰胺作为抑制刺猬信号通路的有效平滑化拮抗剂的鉴定及其构效关系
Bioorg Med Chem Lett. 2009 Jan 15;19(2):328-31. doi: 10.1016/j.bmcl.2008.11.096. Epub 2008 Dec 3.
6
Aberrations and therapeutics involving the developmental pathway Hedgehog in pancreatic cancer.涉及胰腺癌 Hedgehog 发育途径的畸变和治疗。
Vitam Horm. 2012;88:355-78. doi: 10.1016/B978-0-12-394622-5.00016-X.
7
In vitro and in vivo characterization of a novel Hedgehog signaling antagonist in human glioblastoma cell lines.新型 Hedgehog 信号通路拮抗剂在人胶质母细胞瘤细胞系中的体内外鉴定。
Int J Cancer. 2012 Jul 15;131(2):E33-44. doi: 10.1002/ijc.27349. Epub 2012 Jan 31.
8
Advances in Smoothened-targeting therapies for pancreatic cancer: implication for drug discovery from herbal medicines.胰腺癌中靶向Smoothened疗法的进展:对从草药中发现药物的启示。
Zhong Xi Yi Jie He Xue Bao. 2012 Mar;10(3):256-63. doi: 10.3736/jcim20120303.
9
[The inhibition of the Sonic Hedgehog (SHh) pathway improves the effects of chemotherapy in a model of ductal carcinoma of the pancreas in mice].[抑制音猬因子(SHh)信号通路可改善小鼠胰腺导管癌模型中的化疗效果]
Bull Cancer. 2009 Sep;96(9):829.
10
Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer.阻断刺猬信号通路作为胰腺癌的一种治疗策略。
Cancer Lett. 2009 Oct 8;283(2):119-24. doi: 10.1016/j.canlet.2009.01.014. Epub 2009 Feb 15.

引用本文的文献

1
Evaluation of the Value of Fine Needle Aspiration Cytology and Cell Morphology in Determining the Histogenesis of Pancreatic Lesions With Review of Literature, Overview and Cytological Experience of 25 Years: Original Research.细针穿刺细胞学检查及细胞形态学在确定胰腺病变组织发生中的价值评估:文献综述、25年概述及细胞学经验:原创研究
Health Sci Rep. 2025 Jan 12;8(1):e70347. doi: 10.1002/hsr2.70347. eCollection 2025 Jan.
2
A genome-wide association meta-analysis implicates Hedgehog and Notch signaling in Dupuytren's disease.全基因组关联荟萃分析提示 Hedgehog 和 Notch 信号通路与掌腱膜挛缩症相关。
Nat Commun. 2024 Jan 3;15(1):199. doi: 10.1038/s41467-023-44451-0.
3
Locoregional Therapies and Remodeling of Tumor Microenvironment in Pancreatic Cancer.
局部治疗与胰腺癌肿瘤微环境重塑
Int J Mol Sci. 2023 Aug 11;24(16):12681. doi: 10.3390/ijms241612681.
4
Bufalin-Mediated Regulation of Cell Signaling Pathways in Different Cancers: Spotlight on JAK/STAT, Wnt/β-Catenin, mTOR, TRAIL/TRAIL-R, and Non-Coding RNAs.蟾毒灵调节不同癌症中细胞信号通路的作用:聚焦 JAK/STAT、Wnt/β-catenin、mTOR、TRAIL/TRAIL-R 和非编码 RNA。
Molecules. 2023 Feb 27;28(5):2231. doi: 10.3390/molecules28052231.
5
Phase I/II Study of LDE225 in Combination with Gemcitabine and Nab-Paclitaxel in Patients with Metastatic Pancreatic Cancer.LDE225联合吉西他滨和纳米白蛋白结合型紫杉醇治疗转移性胰腺癌的I/II期研究
Cancers (Basel). 2021 Sep 28;13(19):4869. doi: 10.3390/cancers13194869.
6
Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-β/Smad signaling pathways.槲皮素通过抑制 SHH 和 TGF-β/Smad 信号通路抑制胰腺导管腺癌的进展。
Cell Biol Toxicol. 2021 Jun;37(3):479-496. doi: 10.1007/s10565-020-09562-0. Epub 2020 Oct 17.
7
RNA mA Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog Pathway.RNA N⁶-甲基腺嘌呤甲基转移酶METTL3通过调控刺猬信号通路促进前列腺癌生长。
Onco Targets Ther. 2019 Nov 5;12:9143-9152. doi: 10.2147/OTT.S226796. eCollection 2019.
8
Dauricine suppresses the growth of pancreatic cancer by modulating the Hedgehog signaling pathway.蝙蝠葛碱通过调节Hedgehog信号通路抑制胰腺癌的生长。
Oncol Lett. 2019 Nov;18(5):4403-4414. doi: 10.3892/ol.2019.10790. Epub 2019 Sep 3.
9
The Loss of Expression Associated with a Strongly Activated Hedgehog Signaling Pathway Predicts Poor Prognosis in Resected Pancreatic Cancer.与强烈激活的刺猬信号通路相关的表达缺失预示着切除的胰腺癌预后不良。
J Cancer. 2019 Jul 10;10(17):4123-4131. doi: 10.7150/jca.30883. eCollection 2019.
10
The critical roles of activated stellate cells-mediated paracrine signaling, metabolism and onco-immunology in pancreatic ductal adenocarcinoma.活化星状细胞介导的旁分泌信号、代谢和癌免疫学在胰腺导管腺癌中的关键作用。
Mol Cancer. 2018 Feb 19;17(1):62. doi: 10.1186/s12943-018-0815-z.