Suppr超能文献

来自耐辐射球菌的N端截短的Nudix水解酶DR2204的结构

Structure of an N-terminally truncated Nudix hydrolase DR2204 from Deinococcus radiodurans.

作者信息

Gonçalves A M D, Fioravanti E, Stelter M, McSweeney S

机构信息

Macromolecular Crystallography Group, European Synchrotron Radiation Facility, Grenoble, France.

出版信息

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Nov 1;65(Pt 11):1083-7. doi: 10.1107/S1744309109037191. Epub 2009 Oct 13.

Abstract

Nudix pyrophosphatases are a well represented protein family in the Deinococcus radiodurans genome. These hydrolases, which are known to be enzymatically active towards nucleoside diphosphate derivatives, play a role in cleansing the cell pool of potentially deleterious damage products. Here, the structure of DR2204, the only ADP-ribose pyrophosphatase in the D. radiodurans genome that is known to be active towards flavin adenosine dinucleotide (FAD), is presented at 2.0 angstrom resolution.

摘要

Nudix焦磷酸酶是耐辐射球菌基因组中一个有充分代表性的蛋白质家族。这些水解酶对核苷二磷酸衍生物具有酶活性,在清除细胞中潜在有害的损伤产物方面发挥作用。本文展示了DR2204的结构,它是耐辐射球菌基因组中唯一已知对黄素腺嘌呤二核苷酸(FAD)有活性的ADP核糖焦磷酸酶,分辨率为2.0埃。

相似文献

1
Structure of an N-terminally truncated Nudix hydrolase DR2204 from Deinococcus radiodurans.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Nov 1;65(Pt 11):1083-7. doi: 10.1107/S1744309109037191. Epub 2009 Oct 13.
3
Structure of a coenzyme A pyrophosphatase from Deinococcus radiodurans: a member of the Nudix family.
J Bacteriol. 2003 Jul;185(14):4110-8. doi: 10.1128/JB.185.14.4110-4118.2003.
4
The Nudix hydrolases of Deinococcus radiodurans.
Mol Microbiol. 2001 Jan;39(2):286-90. doi: 10.1046/j.1365-2958.2001.02267.x.
5
Structural studies of the Nudix hydrolase DR1025 from Deinococcus radiodurans and its ligand complexes.
J Mol Biol. 2004 May 21;339(1):103-16. doi: 10.1016/j.jmb.2004.01.065.
8
Purification, crystallization and preliminary X-ray analysis of two nudix hydrolases from Deinococcus radiodurans.
Acta Crystallogr D Biol Crystallogr. 2003 Apr;59(Pt 4):737-40. doi: 10.1107/s0907444903002671. Epub 2003 Mar 25.
9

引用本文的文献

1
Characterization of a non-nudix pyrophosphatase points to interplay between flavin and NAD(H) homeostasis in Saccharomyces cerevisiae.
PLoS One. 2018 Jun 14;13(6):e0198787. doi: 10.1371/journal.pone.0198787. eCollection 2018.
2
The evolution of function within the Nudix homology clan.
Proteins. 2017 May;85(5):775-811. doi: 10.1002/prot.25223. Epub 2017 Mar 16.

本文引用的文献

1
Phaser crystallographic software.
J Appl Crystallogr. 2007 Aug 1;40(Pt 4):658-674. doi: 10.1107/S0021889807021206. Epub 2007 Jul 13.
2
A short history of SHELX.
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
3
Structural basis for different substrate specificities of two ADP-ribose pyrophosphatases from Thermus thermophilus HB8.
J Bacteriol. 2008 Feb;190(3):1108-17. doi: 10.1128/JB.01522-07. Epub 2007 Nov 26.
4
The Nudix hydrolase superfamily.
Cell Mol Life Sci. 2006 Jan;63(2):123-43. doi: 10.1007/s00018-005-5386-7.
5
House cleaning, a part of good housekeeping.
Mol Microbiol. 2006 Jan;59(1):5-19. doi: 10.1111/j.1365-2958.2005.04950.x.
7
Structures and mechanisms of Nudix hydrolases.
Arch Biochem Biophys. 2005 Jan 1;433(1):129-43. doi: 10.1016/j.abb.2004.08.017.
8
Coot: model-building tools for molecular graphics.
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32. doi: 10.1107/S0907444904019158. Epub 2004 Nov 26.
9
Refinement of macromolecular structures by the maximum-likelihood method.
Acta Crystallogr D Biol Crystallogr. 1997 May 1;53(Pt 3):240-55. doi: 10.1107/S0907444996012255.
10
Methods used in the structure determination of bovine mitochondrial F1 ATPase.
Acta Crystallogr D Biol Crystallogr. 1996 Jan 1;52(Pt 1):30-42. doi: 10.1107/S0907444995008754.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验