Gonçalves A M D, Fioravanti E, Stelter M, McSweeney S
Macromolecular Crystallography Group, European Synchrotron Radiation Facility, Grenoble, France.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Nov 1;65(Pt 11):1083-7. doi: 10.1107/S1744309109037191. Epub 2009 Oct 13.
Nudix pyrophosphatases are a well represented protein family in the Deinococcus radiodurans genome. These hydrolases, which are known to be enzymatically active towards nucleoside diphosphate derivatives, play a role in cleansing the cell pool of potentially deleterious damage products. Here, the structure of DR2204, the only ADP-ribose pyrophosphatase in the D. radiodurans genome that is known to be active towards flavin adenosine dinucleotide (FAD), is presented at 2.0 angstrom resolution.
Nudix焦磷酸酶是耐辐射球菌基因组中一个有充分代表性的蛋白质家族。这些水解酶对核苷二磷酸衍生物具有酶活性,在清除细胞中潜在有害的损伤产物方面发挥作用。本文展示了DR2204的结构,它是耐辐射球菌基因组中唯一已知对黄素腺嘌呤二核苷酸(FAD)有活性的ADP核糖焦磷酸酶,分辨率为2.0埃。