Dermatology. 2010;220(2):180-2. doi: 10.1159/000259316. Epub 2009 Nov 17.
Segmental hemangioma of infancy is sometimes associated with the development of multiple nonsegmental hemangiomas. Such co-occurrences have so far remained unexplained.
Pertinent reports were collected from the literature. To explicate such cases, the following concept is proposed. Hemangiomas of infancy reflect a polygenic predisposition. Nonsegmental lesions result from a mutational event occurring at a late stage of intrauterine life or after birth, whereas segmental hemangioma originates from loss of heterozygosity or some other mutational event arising at an early developmental stage.
In this way, segmental hemangioma of infancy could be taken as a further example of the superimposed segmental manifestation of a polygenic skin disorder. Future molecular research may show whether this assumption holds true.
婴儿期节段性血管瘤有时与多个非节段性血管瘤的发生有关。到目前为止，这种共存现象仍未得到解释。
从文献中收集了相关报道。为了解释这种情况，提出了以下概念。婴儿血管瘤反映了一种多基因易感性。非节段性病变是由于子宫内生命后期或出生后发生的突变事件引起的，而节段性血管瘤则起源于杂合性丢失或发生在早期发育阶段的其他突变事件。
这样，婴儿期节段性血管瘤可以被视为一种多基因皮肤疾病的节段性表现的叠加的进一步例子。未来的分子研究可能会表明这种假设是否成立。
