Sections of Gastroenterology and Health Services Research, Department of Veterans Affairs Medical Center, Houston, TX, USA.
Pancreas. 2010 May;39(4):458-62. doi: 10.1097/MPA.0b013e3181bd6489.
Cancer of the body/tail of the pancreas is frequently separated from pancreatic head tumors. No studies have examined whether the demographics, disease characteristics, and patient survival with pancreatic body/tail cancers are different from pancreatic head tumors.
We used the Surveillance, Epidemiology, and End Results (SEER) registry to identify 43,946 cases of pancreatic cancer. The yearly incidence and survival rates were calculated. Cox proportional hazards model examined temporal trends in survival.
The incidence rate for pancreatic head cancer has remained at 5.6% per 100,000, whereas the rate for pancreatic body/tail cancers has increased by 46% between 1973 and 2002. The 3-year survival rate has increased slightly for both groups. The Cox proportional hazards model analysis confirms this improvement. The 3-year survival rate for local-stage pancreatic body/tail cancer is 20.0% compared with 9% for local-stage pancreatic head cancer.
This study indicates that the incidence of pancreatic head cancer has remained stable, whereas the incidence of pancreatic body/tail cancers is rising. Despite higher survival rates among patients with pancreatic head cancer compared with those with pancreatic body/tail cancers in several variables, patients with local-stage pancreatic body/tail cancers had higher survival rates compared with local-stage pancreatic head cancer.
体尾部胰腺癌常常与胰头部肿瘤相分离。目前尚无研究探讨体尾部胰腺癌患者的人口统计学特征、疾病特征和生存情况是否与胰头部肿瘤不同。
我们利用监测、流行病学和最终结果（SEER）登记处的数据，确定了 43946 例胰腺癌患者。计算了每年的发病率和生存率。Cox 比例风险模型用于检验生存时间趋势。
胰头部癌症的发病率保持在每 100000 人 5.6%，而 1973 年至 2002 年期间体尾部癌症的发病率增加了 46%。两组的 3 年生存率均略有提高。Cox 比例风险模型分析证实了这一改善。局部期体尾部胰腺癌的 3 年生存率为 20.0%，而局部期胰头部癌症的 3 年生存率为 9%。
本研究表明，胰头部癌症的发病率保持稳定，而体尾部癌症的发病率正在上升。尽管在多个变量中，胰头部癌症患者的生存率高于体尾部癌症患者，但局部期体尾部癌症患者的生存率高于局部期胰头部癌症患者。
