长期严重缺硒对大鼠器官中铁锌含量的影响。

Department of Physical Chemistry, Showa Pharmaceutical University, Tokyo, Japan.

Molecules. 2009 Nov 5;14(11):4440-53. doi: 10.3390/molecules14114440.

The amounts of selenium (Se), iron (Fe), and zinc (Zn) in the liver, kidney, and spleen as a function of age of rats measured using instrumental neutron activation analysis were compared between Se-deficient (SeD) rats and normal rats. The SeD model rats can live for more than 50 weeks. The effect of Se-deficinecy in rats might be weak, compared to the marked malfunction of GSH-Px. The SeD rats can be considered as a model of nonlethal chronic oxidative stress. Fluctuations of Fe and Zn in the liver of Se-deficient rats were observed. The amount of redox-relating minerals, such as Fe and Zn, in SeD rat organs is changeable depending on the age.

采用仪器中子活化分析方法，比较了缺硒（SeD）大鼠和正常大鼠肝脏、肾脏和脾脏中硒（Se）、铁（Fe）和锌（Zn）的含量随大鼠年龄的变化。SeD 模型大鼠可以存活 50 多周。与 GSH-Px 的明显功能障碍相比，硒缺乏对大鼠的影响可能较弱。SeD 大鼠可以被认为是一种非致死性慢性氧化应激的模型。观察到缺硒大鼠肝脏中 Fe 和 Zn 的波动。SeD 大鼠器官中与氧化还原相关的矿物质（如 Fe 和 Zn）的量随年龄而变化。