Gastroenterology Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307, USA.
Aliment Pharmacol Ther. 2010 Feb 15;31(4):509-15. doi: 10.1111/j.1365-2036.2009.04199.x. Epub 2009 Nov 19.
Aeroallergens have been implicated in the pathogenesis of eosinophilic oesophagitis.
To determine whether a seasonal variation exists in the diagnoses of eosinophilic oesophagitis and whether there is a correlation with seasonal pollen count.
A retrospective review was performed from January 2006 to November 2008 to identify eosinophilic oesophagitis patients. Cases were classified by endoscopic date. Daily pollen counts for grass, trees and weeds were obtained from a certified counting station. Per cent of eosinophilic oesophagitis cases were collated seasonally and compared with mean pollen counts for grass, trees and weeds during the same time period.
A total of 127 eosinophilic oesophagitis cases were identified (median age 41, range 19-92 years, 84% men). The highest percentage of cases (33.0%; Binomial P = 0.022) was diagnosed in the spring, while the least percentage (16%; Binomial P = 0.0.010) occurred in the winter. There was a significant association between per cent eosinophilic oesophagitis cases diagnosed seasonally and mean grass pollen count (r(s) = 1.000, P < 0.01), but not with trees (r(s) = 0.400, P = 0.600) or weeds (r(s) = 0.800, P = 0.200).
A seasonal variation was seen in the diagnosis of eosinophilic oesophagitis which correlated with pollen counts. These findings have important implications regarding the pathogenesis of eosinophilic oesophagitis, suggesting a potential role for aeroallergens.
变应原在嗜酸性食管炎的发病机制中起作用。
确定嗜酸粒细胞性食管炎的诊断是否存在季节性变化，以及是否与季节性花粉计数相关。
对 2006 年 1 月至 2008 年 11 月的嗜酸粒细胞性食管炎患者进行回顾性分析。根据内镜日期对病例进行分类。从认证计数站获取草、树和杂草的每日花粉计数。按季节对嗜酸粒细胞性食管炎病例进行分类，并与同期草、树和杂草的平均花粉计数进行比较。
共发现 127 例嗜酸粒细胞性食管炎病例（中位年龄 41 岁，范围 19-92 岁，84%为男性）。春季诊断的病例比例最高（33.0%；二项式 P=0.022），而冬季诊断的病例比例最低（16%；二项式 P=0.010）。季节性诊断的嗜酸粒细胞性食管炎病例比例与平均草花粉计数之间存在显著相关性（r(s)=1.000，P<0.01），但与树木（r(s)=0.400，P=0.600）或杂草（r(s)=0.800，P=0.200）无关。
嗜酸粒细胞性食管炎的诊断存在季节性变化，与花粉计数相关。这些发现对嗜酸粒细胞性食管炎的发病机制具有重要意义，提示变应原可能起作用。
