嗜酸性食管炎的流行病学：它真的是一种新型且不断演变的疾病吗？
Epidemiology of Eosinophilic Esophagitis: Really a Novel and Evolving Disease?
作者信息
Mona Robin, Hruz Petr
机构信息
University Center for Gastrointestinal and Liver Diseases, Clarunis, Basel, Switzerland.
出版信息
Inflamm Intest Dis. 2025 Jan 20;10(1):34-40. doi: 10.1159/000543022. eCollection 2025 Jan-Dec.
BACKGROUND
Eosinophilic esophagitis (EoE) has been described as a chronic allergen/immune-mediated disease characterized by symptoms of esophageal dysfunction and eosinophilic infiltration of the mucosa.
SUMMARY
Over the past decades, EoE has been increasingly recognized in various geographical areas with a high socioeconomic development (mostly industrialized countries) and has evolved from an unknown to a clinically distinct disease with increasing prevalence and incidence. An average age at diagnosis between 30 and 50 years and a male predominance have been consistently observed. In both children and adults, EoE is clearly associated with allergies, predominantly food - but also aeroallergens. Most EoE patients present with a personal allergic background such as asthma, rhino-conjunctivitis, and oral allergy syndrome.
KEY MESSAGE
Knowledge of epidemiological characteristics is crucial for identifying risk factors and understanding of the pathogenic mechanisms.
背景
嗜酸性粒细胞性食管炎（EoE）被描述为一种慢性变应原/免疫介导性疾病，其特征为食管功能障碍症状和黏膜嗜酸性粒细胞浸润。
总结
在过去几十年中，EoE在社会经济高度发达的各个地区（主要是工业化国家）越来越受到认可，并且已从一种未知疾病演变为一种临床特征明显的疾病，其患病率和发病率不断上升。一直观察到诊断的平均年龄在30至50岁之间，且男性居多。在儿童和成人中，EoE均与过敏明显相关，主要是食物过敏，但也有气传变应原过敏。大多数EoE患者有个人过敏史，如哮喘、鼻结膜炎和口腔过敏综合征。
关键信息
了解流行病学特征对于识别危险因素和理解致病机制至关重要。
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