Department of Pathology, Seoul National University Hospital, Seoul, Korea.
Neuropathology. 2010 Jun;30(3):224-31. doi: 10.1111/j.1440-1789.2009.01072.x. Epub 2009 Nov 18.
The transcriptional factor Snail and enzyme cyclo-oxygenase-2 (Cox-2) are suggested to be important effectors of invasiveness and tumorigenesis in various tumors. Tumors of higher grade have the propensity for tumor cell migration and invasiveness. This study was performed in order to evaluate the association between Snail and Cox-2 expressions and their values as prognostic factors in various grades of glioma, Specimens of 56 patients with glioma were used in the study. Univariate analysis showed that WHO tumor grade, and expressions of Snail and Cox-2 were significant prognostic factors affecting overall and disease progression-free survival rates. In the multivariate analysis by Cox regression model, only WHO tumor grade was shown to be a significant independent prognostic factor of overall and progression-free survival rates. In conclusion, Snail and Cox-2 expressions were associated with WHO grade in gliomas and may be used as prognostic indicators.
转录因子 SNAI1 和酶环氧化酶-2（COX-2）被认为是多种肿瘤侵袭和肿瘤发生的重要效应物。高级别肿瘤具有肿瘤细胞迁移和侵袭的倾向。本研究旨在评估 SNAI1 和 COX-2 表达之间的相关性及其作为不同级别胶质瘤预后因素的价值。研究使用了 56 例胶质瘤患者的标本。单因素分析显示，WHO 肿瘤分级、SNAI1 和 COX-2 的表达是影响总生存率和无病生存率的显著预后因素。Cox 回归模型的多因素分析显示，只有 WHO 肿瘤分级是总生存率和无进展生存率的显著独立预后因素。总之，SNAI1 和 COX-2 的表达与胶质瘤的 WHO 分级相关，可作为预后指标。
