Farooqui M Y, Mumtaz M M
Department of Biological Sciences, University of Texas Pan American, Edinburg 78539.
Toxicology. 1991 Jan;65(3):239-50. doi: 10.1016/0300-483x(91)90083-d.
The chemistry, industrial usage, general toxicity and experimental use of methacrylonitrile are briefly reviewed. Methacrylonitrile, a reactive, unsaturated and methylated aliphatic nitrile, has industrial applications in a variety of organic processes related to the polymer industry. Its general toxic effects are primarily related to the release of cyanide and formation of reactive metabolites containing a double bond between carbon 2 and 3. Methacrylonitrile has been given by a variety of routes to mammalian species to study its toxic effects. More recent in vivo and in vitro experimental work concerning its toxicity and metabolism are summarized and possible mechanisms of this chemical's toxic action are discussed.
本文简要回顾了甲基丙烯腈的化学性质、工业用途、一般毒性及实验应用。甲基丙烯腈是一种具有反应活性的不饱和甲基化脂肪腈，在与聚合物工业相关的多种有机工艺中具有工业应用。其一般毒性作用主要与氰化物的释放以及碳2和碳3之间含双键的活性代谢产物的形成有关。已通过多种途径给予哺乳动物甲基丙烯腈以研究其毒性作用。总结了近期关于其毒性和代谢的体内和体外实验工作，并讨论了该化学品毒性作用的可能机制。
