INSERM U 872, Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, Paris, France.
Exp Dermatol. 2010 Feb;19(2):100-7. doi: 10.1111/j.1600-0625.2009.01011.x. Epub 2009 Nov 18.
The mineralocorticoid receptor (MR) and its ligand aldosterone regulate renal sodium reabsorption and blood pressure and much knowledge has been accumulated in MR physiopathology, cellular and molecular targets. In contrast, our understanding of this hormonal system in non-classical targets (heart, blood vessels, neurons, keratinocytes...) is limited, particularly in the mammalian skin. We review here the few available data that point on MR in the skin and that document cutaneous MR expression and function, based on mouse models and very limited observations in humans. Mice that overexpress the MR in the basal epidermal keratinocytes display developmental and post-natal abnormalities of the epidermis and hair follicle, raising exciting new questions regarding skin biology. The MR as a transcription factor may be an unexpected novel player in regulating keratinocyte and hair physiology and pathology. Because its activating ligand also includes glucocorticoids, that are widely used in dermatology, we propose that the MR may be also involved in the side-effects of corticoids, opening novel options for therapeutical intervention.
盐皮质激素受体 (MR) 和其配体醛固酮调节肾脏的钠重吸收和血压，关于 MR 的生理学、细胞和分子靶点已经积累了大量知识。相比之下，我们对该激素系统在非经典靶标（心脏、血管、神经元、角质形成细胞……）中的理解是有限的，特别是在哺乳动物皮肤中。我们在这里回顾了一些现有的数据，这些数据表明 MR 存在于皮肤中，并基于小鼠模型和人类的有限观察，记录了皮肤 MR 的表达和功能。在表皮基底层角质形成细胞中过度表达 MR 的小鼠表现出表皮和毛囊的发育和出生后异常，这引发了关于皮肤生物学的令人兴奋的新问题。作为转录因子的 MR 可能是调节角质形成细胞和头发生理学和病理学的一个意想不到的新因子。由于其激活配体还包括在皮肤科中广泛使用的糖皮质激素，我们提出 MR 也可能参与皮质激素的副作用，为治疗干预开辟了新的选择。
