Andersen Vibeke Charlotte, Vogel Ulla
Medicinsk Afdeling, Regionshospitalet Viborg, DK-8800 Viborg, Denmark.
Ugeskr Laeger. 2009 Nov 16;171(47):3448-51.
Both genetic and environmental factors contribute to the etiology of inflammatory bowel diseases. Recently, progress has been achieved in identifying genetic susceptibility thereby adding to the current knowledge on molecular inflammatory pathways and initiating a wave of emerging drugs based on rational drug design. The lesson to be learned is that many more genes may be involved in disease etiology and that both genome-wide and candidate association studies are necessary for further advances in the field.
遗传因素和环境因素均对炎症性肠病的病因学有影响。最近，在确定遗传易感性方面取得了进展，从而增加了对分子炎症途径的现有认识，并引发了基于合理药物设计的一波新兴药物研发热潮。需要吸取的教训是，可能有更多基因参与疾病病因学，并且全基因组研究和候选基因关联研究对于该领域的进一步进展都是必要的。
