Department of Urology, Friendship Hospital, Capital Medical University, Beijing, China.
J Clin Lab Anal. 2009;23(6):357-61. doi: 10.1002/jcla.20329.
To investigate human epididymis protein 4 (HE4) levels in transitional cell carcinoma (TCC) of the urinary system and its relationship with clinicopathological features.
102 patients with TCC, 60 with benign urinary diseases, and 60 healthy controls were included in this study. The HE4 levels were used to analyze different clinicopathologic characteristics and changes between pre- and postsurgical operation.
The HE4 level was significantly increased in patients with TCC compared to patients with benign urinary diseases patients (P<0.01) and healthy controls (P<0.01), and the level of HE4 in patients with superficial TCC (Tis Ta T1) was significantly higher than that of the benign urogenital group (P<0.05)and healthy controls (P<0.05). There was a significant difference between HE4 levels in patients before and after operation (P<0.05). There was no difference between HE4 levels based on tumor recurrence, clinical TNM stage, lymph node metastasis, or pathological stage (P>0.05). The HE4 level was also different between patients with a single tumor versus patients with multiple tumors. The area under the curves of HE4 is 0.821. The sensitivity and specificity of HE4 at a cutoff value of 45.7 pM were 67.6 and 88.3%, respectively.
HE4 may be a screening tool for early diagnosis of TCC in the urinary system, and may become a prognostic marker for TCC in the urinary system.
研究人附睾蛋白 4（HE4）在泌尿系统移行细胞癌（TCC）中的水平及其与临床病理特征的关系。
本研究纳入了 102 例 TCC 患者、60 例良性泌尿道疾病患者和 60 例健康对照者。使用 HE4 水平分析不同临床病理特征及手术前后的变化。
与良性泌尿道疾病患者（P<0.01）和健康对照组（P<0.01）相比，TCC 患者的 HE4 水平显著升高，且表浅型 TCC（Tis Ta T1）患者的 HE4 水平明显高于良性泌尿组（P<0.05）和健康对照组（P<0.05）。手术前后 HE4 水平差异有统计学意义（P<0.05）。肿瘤复发、临床 TNM 分期、淋巴结转移和病理分期与 HE4 水平无差异（P>0.05）。HE4 水平在单发肿瘤与多发肿瘤患者之间也存在差异。HE4 的曲线下面积为 0.821。当截断值为 45.7 pM 时，HE4 的敏感性和特异性分别为 67.6%和 88.3%。
HE4 可能是泌尿系统 TCC 早期诊断的筛查工具，可能成为泌尿系统 TCC 的预后标志物。
