Allen R D, Grierson J M, Ekberg H, Hawthorne W J, Williamson P, Deane S A, Chapman J R, Stewart G J, Little J M
Pancreas Transplant Research Group, University of Sydney, Westmead Hospital, Australia.
Am J Pathol. 1991 Feb;138(2):303-12.
In preparation for assessment of percutaneous biopsies in our clinical pancreas transplant program, a working knowledge of the histopathologic changes after transplantation was obtained in a longitudinal open biopsy study of 16 dogs receiving bladder-drained whole pancreas allografts. Edema, extravasation of polymorphs, and lymphocytes associated with focal parenchymal injury were early, invariable, and probably nonspecific findings. The initial feature of unmodified rejection was the appearance of capillary and small vein endothelial changes with mainly perivascular inflammatory cell infiltration. Acinar cell loss occurred early and was progressive, whereas islets and ducts were relatively preserved, indicating that acinar tissue may be more vulnerable to lytic necrosis when damaged. Functional rejection, determined by fasting urinary amylase levels, was at a stage of extensive and irreversible necrosis. Functioning grafts in immunosuppressed dogs had minor and transient endothelial changes with absence of class II antigen staining of parenchymal cells.
为在我们的临床胰腺移植项目中评估经皮活检做准备，通过对16只接受膀胱引流式全胰腺同种异体移植的犬进行纵向开放活检研究，获得了移植后组织病理学变化的实用知识。水肿、多形核白细胞外渗以及与局灶性实质损伤相关的淋巴细胞是早期、恒定且可能是非特异性的表现。未缓解排斥反应的初始特征是毛细血管和小静脉内皮细胞改变，并伴有主要的血管周围炎性细胞浸润。腺泡细胞丢失出现早且呈进行性，而胰岛和导管相对保存，这表明腺泡组织受损时可能更容易发生溶解性坏死。根据空腹尿淀粉酶水平确定的功能性排斥反应处于广泛且不可逆坏死阶段。免疫抑制犬的功能性移植物有轻微和短暂的内皮细胞改变，实质细胞无II类抗原染色。
