Tohyama Mikiko, Hashimoto Koji
Department of Dermatology, Ehime University Graduate School of Medicine.
Uirusu. 2009 Jun;59(1):23-30. doi: 10.2222/jsv.59.23.
Drug-induced hypersensitivity syndrome (DIHS) is an adverse reaction with clinical signs of fever, rash, and internal organ involvement. The culprit drugs of DIHS are limited to several drugs such as carbamazepine, phenytoin, phenobarbital, zonisamide, allopurinol, salazosulfapyridine, diaphenylsulphone, and mexiletine. The association of HHV-6 reactivation with DIHS has been known. Flaring of symptoms such as fever and hepatitis is closely related to HHV-6 reactivation. A combination of immunologic reaction to a drug and HHV-6 reactivation results in the severe course of DIHS.
药物性超敏反应综合征（DIHS）是一种伴有发热、皮疹和内脏器官受累临床症状的不良反应。DIHS的致病药物仅限于几种药物，如卡马西平、苯妥英、苯巴比妥、唑尼沙胺、别嘌醇、柳氮磺胺吡啶、二苯砜和美西律。HHV-6再激活与DIHS的关联已为人所知。发热和肝炎等症状的加重与HHV-6再激活密切相关。对药物的免疫反应与HHV-6再激活相结合导致了DIHS的严重病程。
