同时给予65Zn和70Zn后人体锌代谢的动力学分析。

Kinetic analysis of zinc metabolism in humans after simultaneous administration of 65Zn and 70Zn.

作者信息

Wastney M E, Gökmen I G, Aamodt R L, Rumble W F, Gordon G E, Henkin R I

机构信息

Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007.

出版信息

Am J Physiol. 1991 Jan;260(1 Pt 2):R134-41. doi: 10.1152/ajpregu.1991.260.1.R134.

DOI:10.1152/ajpregu.1991.260.1.R134

PMID:1992814

Abstract

Zinc kinetics were studied and compared after oral simultaneous administration of two tracers, radioactive (65Zn) and stable (70Zn) isotope, to four normal human volunteers. Both tracers and zinc concentration were measured in plasma, red blood cells (RBC), urine, and feces for up to 78 days. Radioactive zinc was also measured by external counting over whole body, liver, and thigh. Data from each individual were analyzed using a compartmental model for zinc metabolism. Values calculated for absorption, fractional zinc excretion in urine, exchange with RBC, and secretion into gut using 70Zn data did not differ from values calculated using 65Zn data. Results show that human zinc metabolism can be investigated using stable isotopes as tracers to determine parameters of whole body zinc metabolism, including zinc absorption, excretion, and secretion.

摘要

对四名正常人类志愿者口服同时给予两种示踪剂（放射性（65Zn）和稳定（70Zn）同位素）后，研究并比较了锌动力学。在长达78天的时间里，对血浆、红细胞（RBC）、尿液和粪便中的两种示踪剂以及锌浓度进行了测量。还通过对全身、肝脏和大腿进行外部计数来测量放射性锌。使用锌代谢的房室模型分析了每个个体的数据。使用70Zn数据计算的吸收、尿中锌排泄分数、与红细胞的交换以及向肠道的分泌值与使用65Zn数据计算的值没有差异。结果表明，使用稳定同位素作为示踪剂可以研究人体锌代谢，以确定全身锌代谢的参数，包括锌的吸收、排泄和分泌。