Department of Biological Sciences and Molecular Cellular Physiology, Stanford University, Stanford, California 94305-5430, USA.
Adv Exp Med Biol. 2009;656:65-74. doi: 10.1007/978-1-4419-1145-2_6.
Adenomatous polyposis coli (APC) is a multifunctional protein commonly mutated in colon cancer. APC contains binding sites for multiple proteins with diverse roles in signaling and the structural and functional organization of cells. Recent evidence suggests roles for APC and some of its binding partners in regulating microtubules in mitosis. APC localizes to three key locations in mitosis: kinetochores, the cortex and centrosomes. Here, we discuss possible mechanisms for APC function at these sites and suggest new pathways by which APC mutations promote tumorigenesis.
腺瘤性结肠息肉病（APC）是一种多功能蛋白，在结肠癌中经常发生突变。APC 含有多个结合位点，这些结合位点与信号转导以及细胞的结构和功能组织中的多种蛋白有关。最近的证据表明，APC 及其一些结合伙伴在调节有丝分裂中的微管方面具有作用。APC 在有丝分裂中定位于三个关键位置：动粒、皮质和中心体。在这里，我们讨论了 APC 在这些位置发挥功能的可能机制，并提出了 APC 突变促进肿瘤发生的新途径。
