Lodeta Branimir, Benko Goran, Car Sinisa, Filipan Zoran, Stajcar Damir, Dujmović Tonći
Department of Urology, Varazdin General Hospital, Varazdin, Croatia.
Acta Clin Croat. 2009 Jun;48(2):153-5.
Elevated level of prostatic specific antigen (PSA) is an established parameter to help determine the need to perform prostate biopsy. The aim of the present study was to determine whether PSA density (PSAD) could better predict pathologic finding of 12-core prostate biopsy in men with PSA 4-10 ng/mL than PSA alone. Transrectal ultrasound guided biopsy was performed in 125 men with PSA within this range. The rate of cancer detection was 24%. Study results showed a significant difference in PSAD between the two patient groups with negative and positive biopsy findings (P=0.002), while difference in the measured PSA levels was not significant (P=0.091). Study results suggested that PSAD could serve as an additional parameter in predicting negative outcome of prostate biopsy, with a cut-off value of 0.15 ng/mL/mL within PSA range of 4-10 ng/mL (sensitivity 86.7% and negative predictive value 91.5%).
前列腺特异性抗原（PSA）水平升高是帮助确定是否需要进行前列腺活检的既定参数。本研究的目的是确定在PSA为4 - 10 ng/mL的男性中，PSA密度（PSAD）是否比单独的PSA能更好地预测12针前列腺活检的病理结果。对125名PSA在此范围内的男性进行了经直肠超声引导下的活检。癌症检测率为24%。研究结果显示，活检结果为阴性和阳性的两组患者之间PSAD存在显著差异（P = 0.002），而测得的PSA水平差异不显著（P = 0.091）。研究结果表明，在PSA范围为4 - 10 ng/mL时，PSAD可作为预测前列腺活检阴性结果的一个附加参数，临界值为0.15 ng/mL/mL（敏感性86.7%，阴性预测值91.5%）。
