Dubrovina N I, Zinov'eva D V
Eksp Klin Farmakol. 2009 Sep-Oct;72(5):8-10.
Experiments on C57BL/6J mice of submissive stereotype and behavioral despair response and ASC/Icg mice with high predisposition to catalepsy, which served as depression-like state models, were used to study the influence of benzodiazepine receptor antagonist flumazenil on the restoration of a passive avoidance reaction learned under conditions of the amnesic effect of animal detention in a dark compartment. It is established, that flumazenil (10 mg/kg) reactivated retrieval of the amnesic memory trace in mice of submissive stereotype with the behavioral despair response, while being ineffective in ASC mice.
利用作为类抑郁状态模型的表现顺从刻板行为和行为绝望反应的C57BL/6J小鼠以及对僵住症高度易感的ASC/Icg小鼠，研究苯二氮䓬受体拮抗剂氟马西尼对在动物被关在黑暗隔室的遗忘效应条件下习得的被动回避反应恢复的影响。已确定，氟马西尼（10毫克/千克）可重新激活表现顺从刻板行为和行为绝望反应的小鼠中遗忘记忆痕迹的提取，而对ASC小鼠无效。
