Hombek-Urban Katarzyna A, Króliczewski Jarosław, Szczepaniak Andrzej
Department of Hygiene, Wroclaw Medical University, 7 Mikulicza-Radeckiego St., 50-345 Wroclaw, Poland.
Postepy Biochem. 2009;55(3):299-306.
Both photosynthetic cytochrome b6f complex, and respiratory cytochrome bc1 belong to the family of cytochrome bc complexes. Both protein supercomplexes participate in the transport of electrons, proton translocation through the biological membrane, and they catalyze chinon oxidation as well. The function, composition, spatial organization and biosynthesis of cytochrome b6f complex has been being the subject of research for years. The obtained crystal structures revealed the presence of the third haem in the cytochrome b6, whereas mutagenic experiments indicated the participation of the additional protein factor (TCA) engaged in the regulation of b6f cytochrome complex synthesis through the interaction between TCA and 5'UTR of the PETA transcript. The following compendium is the collection of the current data and knowledge with reference to the structure and biogenesis of the above mentioned protein complex.
光合细胞色素b6f复合体和呼吸细胞色素bc1都属于细胞色素bc复合体家族。这两种蛋白质超复合体都参与电子传递、质子跨生物膜转运，并且它们也催化醌氧化。多年来，细胞色素b6f复合体的功能、组成、空间组织和生物合成一直是研究的主题。获得的晶体结构揭示了细胞色素b6中存在第三种血红素，而诱变实验表明，额外的蛋白质因子（TCA）通过TCA与PETA转录本的5'UTR之间的相互作用参与细胞色素b6f复合体合成的调控。以下纲要收集了关于上述蛋白质复合体的结构和生物发生的当前数据和知识。
