Frankowski Kamil, Swiezawska Brygida, Wilmowicz Emilia, Kesy Jacek, Kopcewicz Jan
Department of Physiology and Molecular Biology of Plants, Institute of General and Molecular Biology, Nicolaus Copernicus University, 9 Gagarina St, 87-100 Toruń, Poland.
Postepy Biochem. 2009;55(3):337-41.
Significant progress which was made during last few years in research of jasmonic acid signaling pathway yielded surprising information about chemical form of a signaling molecule of the hormone, which turned out to be its conjugate with amino acid isoleucine. Function of jasmonic acid receptor is more and more frequently attributed to COI1 protein which is structurally and functionally similar to the auxin receptor TIR1. Signal perception takes place in the nucleus and leads to the activation of SCF(COI1) ubiquitine ligase and consequently to proteolysis of transcription repressors, the JAZ proteins. Reduced pool of these negative regulators enables to activate the transcription factors (i. e. ERF1, WRKY70, MYC2), as well as expression of genes involved in defense responses of plants (i. e. PDF1.2, VSP1, CHI-B). Jasmonic acid signal transduction pathway, is also subjected to complicated regulations, including both positive, and negative feedbacks, which enable plants react adequately to variable environmental conditions.
在过去几年中，茉莉酸信号通路的研究取得了重大进展，产生了关于该激素信号分子化学形式的惊人信息，结果表明它是与氨基酸异亮氨酸的共轭物。茉莉酸受体的功能越来越多地归因于COI1蛋白，其在结构和功能上与生长素受体TIR1相似。信号感知发生在细胞核中，导致SCF(COI1)泛素连接酶的激活，进而导致转录抑制因子JAZ蛋白的蛋白水解。这些负调控因子数量的减少使得能够激活转录因子（如ERF1、WRKY70、MYC2），以及参与植物防御反应的基因（如PDF1.2、VSP1、CHI-B）的表达。茉莉酸信号转导途径也受到复杂的调控，包括正反馈和负反馈，这使植物能够对多变的环境条件做出充分反应。
