Gabryelska Marta M, Szymański Maciej, Barciszewski Jan
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Z. Noskowskiego 12/14, 61-704 Poznań, Poland.
Postepy Biochem. 2009;55(3):342-54.
DNA, one of the most famous molecules is 140-years-old. Its history has engaged three centuries of experiments, leading us to a point, where the Homo sapiens genome sequence is known. The "DNA breakthrough" is dated on 1953, when James Watson and Francis Crick proposed the model of molecular structure of DNA. But the origin of that great achievement goes back to 1869 and early efforts of Friedrich Miescher, the Swiss doctor, who isolated DNA (than termed nuclein) for the first time. Since that time wealth information on "nuclein", its functions, structure and usage has been collected and formed a basis for modern molecular biology, chemical biology and biotechnology. This article describes the events and circumstances of the most important DNA discoveries since its first isolation up to completing the human genome project and deep DNA sequencing techniques application.
DNA，最著名的分子之一，已有140年历史。其历史涉及三个世纪的实验，引领我们走到了如今人类基因组序列已知的阶段。“DNA突破”可追溯到1953年，当时詹姆斯·沃森和弗朗西斯·克里克提出了DNA分子结构模型。但这一伟大成就的起源可追溯到1869年，瑞士医生弗里德里希·米舍尔的早期努力，他首次分离出了DNA（当时称为核素）。从那时起，关于“核素”及其功能、结构和用途的丰富信息被收集起来，为现代分子生物学、化学生物学和生物技术奠定了基础。本文描述了从首次分离DNA到完成人类基因组计划以及深度DNA测序技术应用以来最重要的DNA发现的事件和情况。
