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缺血性结肠炎。是一个不断变化的疾病谱吗?

Ischemic colitis. An ever-changing spectrum?

作者信息

Parish K L, Chapman W C, Williams L F

机构信息

Department of Surgery, Nashville Veterans Administration Medical Center, Tennessee.

出版信息

Am Surg. 1991 Feb;57(2):118-21.

PMID:1992867
Abstract

Ischemic colitis, or more properly colonic ischemia, became a clear clinical entity in the past 25 years. Yet, early diagnosis of this disease with its various presentations remains a difficult task. A 10-year review at our hospital identified 38 patients with colonic ischemia for comparison with the authors' previous experience and with data from the literature. Several important factors emerge: (1) Twice as many cases occurred after operations (34% in this series vs. 16% in the past), probably because fewer and fewer spontaneous cases were hospitalized. (2) Sixteen patients required operative intervention for colonic ischemia with a mortality of 62 per cent, while those treated nonoperatively had a mortality of 14 per cent. Seven of eight postoperative patients who required a second operative procedure for their colonic ischemia died. A high clinical suspicion is necessary in the postoperative patient, as colonic ischemia appears to be more severe among these patients. Moreover, the high incidence of associated cardiovascular disease indicates that early diagnosis, as well as monitoring of the "at-risk" patient, is needed for improvement in survival to occur. New monitoring methods, such as tonometry, may help accomplish this goal.

摘要

缺血性结肠炎,或者更确切地说是结肠缺血,在过去25年中已成为一种明确的临床病症。然而,对这种具有多种表现形式的疾病进行早期诊断仍然是一项艰巨的任务。我们医院进行的一项为期10年的回顾性研究确定了38例结肠缺血患者,以便与作者之前的经验以及文献数据进行比较。出现了几个重要因素:(1)手术后继发病例是过去的两倍(本系列中为34%,过去为16%),这可能是因为因自发病例住院的患者越来越少。(2)16例结肠缺血患者需要手术干预,死亡率为62%,而非手术治疗的患者死亡率为14%。8例因结肠缺血需要二次手术的术后患者中有7例死亡。对于术后患者,高度的临床怀疑是必要的,因为结肠缺血在这些患者中似乎更为严重。此外,相关心血管疾病的高发病率表明,需要对“高危”患者进行早期诊断和监测,以提高生存率。新的监测方法,如张力测定法,可能有助于实现这一目标。

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