Mabuchi E, Shimizu K, Yamada M, Moriuchi S, Park K, Tamura K, Hayakawa T, Mogami H
Dept. of Neurosurgery, Osaka University Medical School, Japan.
Gan To Kagaku Ryoho. 1991 Feb;18(2):233-8.
We performed an in vitro chemosensitivity test with 8 malignant brain tumor cell lines, which were established in our Department. It was shown that ACNU was moderately tumoricidal against only one cell (ONS-86) line. IFN-beta (interferon-beta) was more active against 4 cell (ONS-6, -20, -76, and -81) lines. VCR (vincristine), MTX (methotrexate), and Ara-C (cytosine arabinoside) and FK 973 were most effective against all 8 cell lines. There were some difference in the drug sensitivities among the tumors with the same pathological diagnosis. Since IFN-beta was tumoricidal against to the cells, co-culture of IFN-beta and one of other antitumor agents seemed to induce more antitumor effects. With regard to the side effects of IFN-beta, the combined therapy with IFN-beta and other drugs induced more antitumor effects against malignant brain tumor cells and seemed to reduce the side effects.
我们对本科室建立的8种恶性脑肿瘤细胞系进行了体外化学敏感性试验。结果显示，阿糖胞苷（ACNU）仅对一种细胞系（ONS - 86）具有中度杀瘤作用。β干扰素（IFN - β）对4种细胞系（ONS - 6、- 20、- 76和 - 81）活性更强。长春新碱（VCR）、甲氨蝶呤（MTX）、阿糖胞苷（Ara - C）和FK 973对所有8种细胞系最为有效。相同病理诊断的肿瘤之间药物敏感性存在一些差异。由于IFN - β对细胞具有杀瘤作用，IFN - β与其他抗肿瘤药物之一共同培养似乎能诱导更强的抗肿瘤作用。关于IFN - β的副作用，IFN - β与其他药物联合治疗对恶性脑肿瘤细胞诱导出更强的抗肿瘤作用，且似乎能减少副作用。
